Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger,
Peer Review Status: Externally Peer Reviewed
Human, Helly's fluid, H. & E., 612 x.
Developing muscle fibers are seen in different stages of development. Embryonic muscle fibers are characterized by centrally placed nuclei and peripherally disposed myofibrils. These fibers grow in length and diameter by myoblast fusion. No nuclear divisional figures are ordinarily seen at this stage. As the muscle fiber matures, the nuclei become located primarily beneath the sarcolemma at the periphery of the fiber.
A congenital disorder of skeletal muscle seen in children (centrovacuolar myopathy) is characterized by a histologic picture identical with that seen in embryonic skeletal muscle.
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