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Anatomy Atlases: Atlas of Microscopic Anatomy: Section 1 - Cells Atlas of Microscopic Anatomy: Section 6 - Nervous Tissue

Plate 6.111 Vasoactive Intestinal Polypeptide (VIP)

Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger, Jr., Ph.D.
Peer Review Status: Externally Peer Reviewed

Myenteric and submucosal plexuses
A. ileum B. colon

 Plate 6.111 Vasoactive Intestinal Polypeptide (VIP)

Mouse, modified ABC (avidin-biotin complex)
immunoperoxidase technique, A., B., 350 x.

The upper illustration (A) is of VIP containing nerve fibers of the myenteric plexus (of Auerbach*) as confirmed by the subtle cross-hatched appearance caused by the outer longitudinal and inner circular layers of smooth muscle fibers. The latter shows some background staining.

The lower illustration (B) is of VIP containing axons and ganglion cell bodies of the submucosal plexus (of Meissner*).

VIP is believed to increase intestinal motility.

*Auerbach was a nineteenth-century German anatomist and Meissner was a nineteenth-century German histologist.

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