Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger,
Peer Review Status: Externally Peer Reviewed
Rhesus monkey, 10% formalin, H. & E., 162 x.
This plate shows the cellular changes in the process of keratinization. The stratified squamous epithelium covering a filiform papilla is seen. Note the keratohyalin granules in cells of the zona granulosa. In the more superficial zona pellucida, the cells lose their keratohyalin granules and become flattened and elongated; some lose their nuclei. The cytoplasm of these cells appears homogeneous. In the most superficial zone, the cells become clear and flattened.
The structural changes in keratinization involve aggregation and arrangement of filaments, formation of keratohyalin granules, and loss of cell organelles as a result of the accumulation of these granules. Desquamated cells are continually replaced by new cells that are formed in the germinative basal layer and move toward the surface during the process of keratinization.
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