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Anatomy Atlases: Atlas of Microscopic Anatomy: Section 1 - Cells Atlas of Microscopic Anatomy: Section 9 - Lymphatic System

Plate 9.174 Spleen: White Pulp splenic nodule

Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger, Jr., Ph.D.
Peer Review Status: Externally Peer Reviewed

White Pulp splenic nodule

Plate 9.174 Spleen: White Pulp splenic nodule

Rhesus monkey, Helly's fluid, H. & E., 162 x.


White pulp: Compact lymphatic tissue sheath surrounding the central arteriole. This sheath forms ovoid enlargements at intervals. The enlargements, known as lymphatic nodules, splenic nodules or Malpighian* corpuscles, may have germinal centers. Blends into the adjacent red pulp. Lymphocytes are the predominant cellular element, but plasma cells, macrophages, and other free cells are also found.

Red pulp: Less compact lymphatic tissue. Traversed by venous channels (sinusoids), imparting to it a reddish color in the fresh or unfixed state. Looks somewhat compact in fixed preparation because of the collapse of sinusoids.

Lymphocytes: Large, medium-sized, and small lymphocytes constitute the principal cell types found in the white pulp. They are compactly arranged in the white pulp and more loosely arranged in the red pulp.

Central arteriole: Courses in the white pulp. Adventitia is replaced by reticular tissue, which is infiltrated by lymphocytes in the white pulp. Supplies capillaries to the white pulp.

*Malpighi was a seventeenth-century Italian anatomist.

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