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Anatomy Atlases: Atlas of Microscopic Anatomy: Section 1 - Cells Atlas of Microscopic Anatomy: Section 17 - Central Nervous System

Plate 17.320 Spinal Cord

Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger, Jr., Ph.D.
Peer Review Status: Externally Peer Reviewed

Primary lateral sclerosis

Plate 17.320 Spinal Cord

Human, 10% formalin, Weil, 8 x.


This is a section of the spinal cord stained with Weil's method. This method stains normal myelinated fiber tracts black. The lightly stained lateral corticospinal tract stands out in contrast to the darkly stained normal myelin elsewhere in the spinal cord. This selective loss of myelinated fibers in the lateral corticospinal tract is characteristic of a spinal cord disorder known as primary lateral sclerosis. Patients afflicted with this disorder show all the signs of upper motor neuron lesion, including weakness, spasticity, hyperreflexia, Babinski* reflex, and clonus.

*Babinski was a nineteenth-century French (Paris) neurologist.  

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