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Anatomy Atlases: Atlas of Microscopic Anatomy: Section 1 - Cells Atlas of Microscopic Anatomy: Section 4 - Blood

Plate 4.53: Lymphocytes

Small and large lymphocytes

Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger, Jr., Ph.D.
Peer Review Status: Externally Peer Reviewed

Small and large lymphocytes

Plate 4.53: Lymphocytes

Human, air-dried blood smear, Wright's stain, 1416 x.


Small lymphocytes: These are the most common type in normal blood. They have a large, dense, round nucleus and thin basophilic cytoplasm and are capable of ameboid movement and the production of antibodies.

Large lymphocytes: These are not very common in normal blood. The nucleus is indented, and cytoplasm is more abundant than in small lymphocytes. Azurophilic granules are frequently found in large lymphocytes; they are less commonly detected in small lymphocytes.

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