Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger,
Peer Review Status: Externally Peer Reviewed
Rat, Seligman acetylcholinesterase method, 612 x.
Enzyme location: The muscle sarcolemma that forms the primary and secondary clefts of the subneural apparatus is rich in acetylcholinesterase activity. Axon terminals (not seen in this preparation) lie within the primary synaptic cleft (refer to Plates 117 and 118) and liberate acetylcholine when a nerve action potential, originating in the spinal cord, arrives at the nerve endings. Acetylcholine results in the depolarization of the muscle membrane and the appearance of a muscle action potential, which spreads over the muscle fiber leading to muscular contraction. The acetylcholine is hydrolyzed by the enzyme located on the sarcolemma beneath the nerve terminals, and the sarcolemma is repolarized in preparation for the next nerve impulse.
Seligman was a twentieth-century American histochernist and surgeon.
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