Ronald A. Bergman, Ph.D., Adel K. Afifi, M.D., Paul M. Heidger,
Peer Review Status: Externally Peer Reviewed
Rhesus monkey, Helly's fluid, H. & E., 162 x.
Cortex: This is located underneath the capsule. Formed of a series of closely packed regularly arranged lymph nodules.
Medulla: Formed of anastomosing cords of lymphocytes separated by the abundant lymphatic sinuses.
Capsule: Well-defined connective tissue cover from which septa or trabeculae penetrate the substance of the lymph node.
Cortical sinus: Lymphatic sinus separates cortical nodules from the capsule. Lymph from the afferent lymphatic vessels enters the node via the cortical sinus.
Lymph nodule: Closely packed aggregate of lymphocytes in the cortex of the node. Also known as cortical follicles or primary nodules. Lymphatic nodules are temporary structures that may develop, disappear, and redevelop. The size and number of nodules vary widely.
Germinal center: Also known as secondary nodule or reaction center. The lighter-staining area in the center of the lymph nodule. It varies in size with age, being best developed in childhood. It is believed to be a cytogenic or lymphocytopoietic center. It is a temporary structure like lymph nodules.
Blood vessels: Branches of the artery that enter at the hilus of the node.
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